XL 188

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

XL188 (XL-188) 是一种有效的、选择性的、USP7 非共价活性位点抑制剂，对 USP7 全长酶和催化结构域的 IC50 分别为 90 nM 和 193 nM。

XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively; exhibits little to no inhibition against a panel of 41 DUBs; promotes USP7-dependent loss of HDM2 and increases p53 and p21, significantly blocks labeling of USP7 by HA-Ub-Vs with an IC50 of 0.9 uM; a probe suitable for in vivo studies, highly valuable for pharmacological validation of USP7 in animal disease models.

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XL-188 | XL188

Proteasome/Ubiquitin

DUB

DUB

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574.726

C32H42N6O4

>98% (HPLC)

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(R)-N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)-3-(4-methylpiperazin-1-yl)propanamide

(-20℃)

With Ice Pack

≥ 2 years