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XL 188
CAS No. ——
XL 188 ( XL-188;XL188 )
产品货号. M17000 CAS No. ——
XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 200MG | 获取报价 | 有现货 |
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生物学信息
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产品名称XL 188
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.
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产品描述XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively; exhibits little to no inhibition against a panel of 41 DUBs; promotes USP7-dependent loss of HDM2 and increases p53 and p21, significantly blocks labeling of USP7 by HA-Ub-Vs with an IC50 of 0.9 uM; a probe suitable for in vivo studies, highly valuable for pharmacological validation of USP7 in animal disease models.
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同义词XL-188;XL188
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通路Proteasome/Ubiquitin
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靶点DUB
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受体DUB
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量574.73
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分子式C32H42N6O4
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称(R)-N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)-3-(4-methylpiperazin-1-yl)propanamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lamberto I, et al. Cell Chem Biol. 2017 Sep 28. pii: S2451-9456(17)30329-X.
产品手册
关联产品
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USP10-IN-3
USP10-IN-3 is a HBX19818 analog, potent and selective USP10 inhibitor, but does not inhibit USP7 (IC50>100 uM).
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USP7-IN-4
(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays.
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HBX-19818
HBX-19818is apotent, selective USP7 inhibitor with IC50 of 28.1 uM.
